After the Champions League game, Liverpool host Arsenal in the league on Sunday.
Arsenal scored twice in the last six minutes to secure a 3-1 home victory over Fulham that left their London rivals deep in relegation danger.
City open the season on Aug. 11, with the final round of matches scheduled for May 19, 2024.
Last season's beaten finalists Arsenal travel to Blackburn Rovers, while Manchester City play Tottenham Hotspur and West Ham United host Everton in the other games.
Irresistible Chelsea go into the Christmas round of fixtures knowing they can end the year by re-writing the record books.
Liverpool belatedly kick-started their year and damaged Tottenham Hotspur's slender Premier League title hopes as Sadio Mane struck both goals in a 2-0 victory at Anfield.
Manchester City survived a stirring Leicester City fightback to claim a 2-1 win that lifted them above Liverpool into third in the Premier League on Saturday.
Arsenal will have to produce the biggest second leg comeback in a Champions League knockout tie to avoid a seventh successive exit at the last 16 stage when they host Bayern Munich on Tuesday.
Free from the extra burden of European football, Liverpool have a strong chance to win the Premier League this season under a "ruthless" Juergen Klopp, according to Bayern Munich striker Robert Lewandowski. Liverpool, who finished eighth in the league standings last season, are fourth in the table this campaign, having beaten Arsenal, Chelsea and champions Leicester City in their opening seven games.
A five-point lead at the top of the Premier League should have been enough to put a smile on Arsene Wenger's face, yet it was the convincing manner of Saturday's 2-0 victory over Liverpool that most pleased the Arsenal manager.
A five-point lead at the top of the Premier League should have been enough to put a smile on Arsene Wenger's face, yet it was the convincing manner of Saturday's 2-0 victory over Liverpool that most pleased the Arsenal manager.
Arsenal fought back from 2-0 down to beat Bolton Wanderers 4-2 and go top of the Premier League while Liverpool re-ignited their season with a 2-0 win over Tottenham Hotspur on Wednesday.
Arsenal exacted revenge against Liverpool on Sunday, Everton kept a dream alive for their manager and Sheffield United caused a dramatic old-fashioned upset as they all reached the FA Cup quarter-finals.
Manchester United manager Alex Ferguson dismissed Chelsea's Premier League title hopes on Wednesday.
Chelsea went second in the Premier League with a comfortable 4-0 win at Burnley, on Sunday, which maintained their unbeaten start to the season.
Arsenal's hopes of catching Manchester City for second place in the Premier League suffered a setback.
The Londoners are fourth in the Premier League table, 13 points behind leaders Leicester City with five games left.
'I think 70-80 percent of the goals we have conceded are from set pieces. But they are all different and we are still working on it and we defended against Manchester United brilliantly'
Alexis Sanchez and Olivier Giroud were on target as Arsenal won 2-0 at Southampton on Wednesday to move up to fifth in the Premier League and fuel their hopes of a late push for the top four.
Goalkeeper De Gea was forced to leave the field during Spain's Euro 2020 qualifier against Sweden on Tuesday.
Liverpool cruised past Watford 3-0 away to claim their seventh win in their last eight league games.
Liverpool, Chelsea and Manchester United celebrated the festive season with victories on Friday while Arsenal, the other member of the 'big four', squandered a 2-0 lead to draw 2-2 at Aston Villa. Liverpool beat Bolton Wanderers 3-0 at Anfield with Robbie Keane scoring twice to give the leaders 42 points, one ahead of Chelsea as the Premier League season reached the halfway point.
Arsenal scored twice in the opening seven minutes and ended the match as a contest with a third in the 19th as they crushed Manchester United 3-0 to move above them into second place in the Premier League at the Emirates on Sunday.
UEFA issued a strong statement jointly with English, Spanish and Italian leagues and football federations, saying they were ready to use "all measures" to confront any breakaway and saying any participating clubs would be banned from domestic leagues, such as the Premier League.
Champions and Premier League leaders Chelsea suffered their second defeat of the season as Fernando Torres scored twice to guide resurgent Liverpool to a deserved 2-0 victory at Anfield on Sunday.
Liverpool have agreed a deal to sign Real Madrid playmaker Nuri Sahin on a season-long loan, the English Premier League club said on Saturday.
The strip made a memorable debut in the 7-0 thrashing of Maribor in the Champions League group stage, marking Liverpool's biggest ever away win in European competition.
Chelsea moved within two points of fourth-placed Tottenham Hotspur in the Premier League after a 1-0 victory over Liverpool thanks to an Olivier Giroud header at Stamford Bridge on Sunday.
Norway captain Brede Hangeland scored a first-half goal to hand Fulham, who escaped relegation on the final day of last season, an upset 1-0 home win over Arsenal in the English Premier League on Saturday. Liverpool captain Steven Gerrard scored four minutes into stoppage time to cap a thrilling 2-1 comeback victory over Middlesbrough at Anfield that gives his side maximum points after two rounds.
Arsenal will begin their quest to become the first club since 1886 to win the English FA Cup three years in succession.
IMAGES from the English Premier League match played on Saturday
Liverpool ripped apart Manchester City with three goals inside the opening 31 minutes as they won their Champions League quarter-final, first leg tie 3-0 on Wednesday.
Tottenham Hotspur scored a 2-0 victory at Manchester City, whilst Arsenal posted a 3-2 victory at Blackburn Rovers.
The result left the top positions in the Premier League unchanged. Arsenal lead the standings with 47 points, followed by Manchester United (45).
Holders Manchester City beat Chelsea 1-0 with a late Bernardo Silva goal on Saturday to reach the FA Cup final after an absorbing end-to-end Wembley semi-final left the exhausted winners still chasing a domestic double.
Arsenal and Manchester United will be out to make amends after a weekend of damaging results when they meet at The Emirates in the Premier League on Wednesday.
Liverpool, who are fifth in the table and have won just one league game since the turn of the year, host fourth-placed Arsenal on Saturday looking to bounce back immediately from one of their worst performances of the season.