Arsenal exacted revenge against Liverpool on Sunday, Everton kept a dream alive for their manager and Sheffield United caused a dramatic old-fashioned upset as they all reached the FA Cup quarter-finals.
Arsenal fought back from 2-0 down to beat Bolton Wanderers 4-2 and go top of the Premier League while Liverpool re-ignited their season with a 2-0 win over Tottenham Hotspur on Wednesday.
Goalkeeper De Gea was forced to leave the field during Spain's Euro 2020 qualifier against Sweden on Tuesday.
Images from Saturday's action in the Premier League.
Manchester United manager Alex Ferguson dismissed Chelsea's Premier League title hopes on Wednesday.
UEFA issued a strong statement jointly with English, Spanish and Italian leagues and football federations, saying they were ready to use "all measures" to confront any breakaway and saying any participating clubs would be banned from domestic leagues, such as the Premier League.
The Londoners are fourth in the Premier League table, 13 points behind leaders Leicester City with five games left.
Arsenal's hopes of catching Manchester City for second place in the Premier League suffered a setback.
Alexis Sanchez and Olivier Giroud were on target as Arsenal won 2-0 at Southampton on Wednesday to move up to fifth in the Premier League and fuel their hopes of a late push for the top four.
'I think 70-80 percent of the goals we have conceded are from set pieces. But they are all different and we are still working on it and we defended against Manchester United brilliantly'
Liverpool, Chelsea and Manchester United celebrated the festive season with victories on Friday while Arsenal, the other member of the 'big four', squandered a 2-0 lead to draw 2-2 at Aston Villa. Liverpool beat Bolton Wanderers 3-0 at Anfield with Robbie Keane scoring twice to give the leaders 42 points, one ahead of Chelsea as the Premier League season reached the halfway point.
Liverpool cruised past Watford 3-0 away to claim their seventh win in their last eight league games.
Arsenal scored twice in the opening seven minutes and ended the match as a contest with a third in the 19th as they crushed Manchester United 3-0 to move above them into second place in the Premier League at the Emirates on Sunday.
The strip made a memorable debut in the 7-0 thrashing of Maribor in the Champions League group stage, marking Liverpool's biggest ever away win in European competition.
Champions and Premier League leaders Chelsea suffered their second defeat of the season as Fernando Torres scored twice to guide resurgent Liverpool to a deserved 2-0 victory at Anfield on Sunday.
Arsenal play away to City on Wednesday hoping to regain their grip on the title race after securing draws in their last three games.
Chelsea moved within two points of fourth-placed Tottenham Hotspur in the Premier League after a 1-0 victory over Liverpool thanks to an Olivier Giroud header at Stamford Bridge on Sunday.
IMAGES from the English Premier League match played on Saturday
Liverpool have agreed a deal to sign Real Madrid playmaker Nuri Sahin on a season-long loan, the English Premier League club said on Saturday.
Liverpool ripped apart Manchester City with three goals inside the opening 31 minutes as they won their Champions League quarter-final, first leg tie 3-0 on Wednesday.
IMAGES from the EPL matches played on Wednesday.
Norway captain Brede Hangeland scored a first-half goal to hand Fulham, who escaped relegation on the final day of last season, an upset 1-0 home win over Arsenal in the English Premier League on Saturday. Liverpool captain Steven Gerrard scored four minutes into stoppage time to cap a thrilling 2-1 comeback victory over Middlesbrough at Anfield that gives his side maximum points after two rounds.
Arsenal will begin their quest to become the first club since 1886 to win the English FA Cup three years in succession.
Liverpool, who are fifth in the table and have won just one league game since the turn of the year, host fourth-placed Arsenal on Saturday looking to bounce back immediately from one of their worst performances of the season.
Liverpool will attempt to sweep away the January blues on the last day of a wretched month when they host commanding Premier League leaders Chelsea at Anfield on Tuesday.
Tottenham Hotspur scored a 2-0 victory at Manchester City, whilst Arsenal posted a 3-2 victory at Blackburn Rovers.
The result left the top positions in the Premier League unchanged. Arsenal lead the standings with 47 points, followed by Manchester United (45).
Liverpool regained their place at the top of the English Premier League with a 2-0 win at Cardiff City on Sunday that restored their two-point lead over Manchester City
Arsenal and Manchester United will be out to make amends after a weekend of damaging results when they meet at The Emirates in the Premier League on Wednesday.
Images from the English Premier League matches played on Saturday
Chelsea's Didier Drogba proved Arsenal's nemesis again on Sunday when he scored the opening goal in the champions' 2-0 win over their London rivals which stretched their lead at the top of the Premier League. Blackpool also had an afternoon to remember, with a shock 2-1 win at Liverpool, which left Roy Hodgson's mis-firing side in the bottom three.
Phil Foden kept Manchester City's Premier League title challenge on track with a superb second-half double as his side hit back to clinch a 3-1 home victory over Manchester United on Sunday.
Arsenal joined Manchester United and Liverpool on the FA Cup scrapheap on Sunday when Ricardo Fuller's double helped Stoke City to a 3-1 fourth round victory at the Britannia Stadium.
Wolves took the lead a minute later when Rayan Ait-Nouri's cross found Sarabia poorly marked in the middle of the box. The Spain international headed past Grbic to score his third goal in the campaign.
England begin their World Cup group campaign against Iran on November 21.
A round-up of the soccer matches played accross Europe over the weekend.
Wayne Rooney scored twice to help Manchester United stretch their unbeaten run to 12 games in an entertaining 2-2 Premier League draw at Tottenham Hotspur and Liverpool were upset 3-1 at HullCity on Sunday.